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Hypothetical pathway involved in the proinflammatory effects of Cdtsp 2 on mouse tissue. Cdtsp 2 induces edema via an enzymatic cleavage of PAR1 and PAR2 coupled with a G-protein, subsequently activating PLC and PKC. Consequently, an increase in cPLA2 activity is triggered by an increase in AA metabolism and its interplay with oxidative stress.
