Figure 1.
In vivo efficacy of compound 13 in a mouse model of C. difficile infection. Two groups of mice (UK6 and UK6 +13, n=10 per group) were challenged with C. difficile spores at 106 per mouse in the absence or presence of compound 13, after pretreatment of antibiotics. The third group mice (n=5) were administered compound 13 only as controls. a) Percent of diarrhea with or without treatment of compound 13. b) Survival rates of mice with or without treatment of compound 13. Results were analyzed by two-way ANOVA. The differences between the UK6 group and the treatment group (UK6+13) are statistically significant, p<0.05.