Table 1.

Structures of compounds 1–16 and their antibacterial activity against C. difficile.

Compd	Structure	logP[a]	MIC [μg mL−1]	Compd	Structure	logP[a]	MIC [μg mL−1]
1		1.21	128	9		6.12	2.0
2		2.28	32	10		4.31	8.0
3		3.17	32	11		5.58	2.0
4		3.23	8.0	12		5.31	1.0
5		5.51	1.0	13		5.38	1.0
6		6.56	1.0	14		5.78	1.0
7		5.57	4.0	15		5.72	1.0
8		5.55	1.0	16		5.01	1.0
	vancomycin	-	0.5

^[a]Calculated by Alogps version 2.1 software.