Fold change of key metabolites, (a) 9- and 13-HODE, (b)
lauroylcarnitine, (c) glycerol, (d) 5-oxoproline,
(e) γ-glutamylglutamine, (f) methionine,
(g) cysteine, (h) glycochenodeoxycholate,
(i) taurodeoxycholate, (j) adenosine
5′-diphosphate, (k) 7-β-hydroxycholesterol,
(l) xanthosine, (m) sphingosine-1-phosphate,
(n) N-stearoyl taurine, and (o)
serotonin, were identified after ultra-high performance liquid chromatography
and tandem mass spectrometry combined with gas chromatography/mass spectrometry
(see Materials and Methods section for details). Values represent the mean
± standard error of the mean. n = 60 for the psoriasis group, n
= 30 for the healthy group. P-values were derived from
the Welch t test. P < 0.05 was considered
statistically significant.