Table 1.
Patient Characteristics by Study and Total Samples
| Characteristic | Mean (SD) | |||||
|---|---|---|---|---|---|---|
| All Patients |
Patients With eGFR >40 mL/min/1.73 m2 |
|||||
| All | 4C Study14,15 | ESCAPE Trial3 | All | 4C Study14,15 | ESCAPE Trial3 | |
| Total No. | 898 | 642 | 256 | 269 | 100 | 169 |
| Age, y | 11.9 (3.5) | 12.2 (3.3) | 11.2 (3.9) | 11.6 (3.7) | 12.7 (3.0) | 11.0 (3.9) |
| Male, No. (%) | 560 (62.4) | 414 (64.5) | 146 (57.0) | 165 (61.3) | 72 (72.0) | 93 (55.0) |
| Diagnosis, No. (%) | ||||||
| CAKUT, refluxive/obstructive | 427 (47.6) | 323 (50.3) | 104 (40.6) | 123 (45.7) | 59 (59.0) | 64 (37.9) |
| CAKUT, other | 210 (23.4) | 124 (19.3) | 86 (33.6) | 79 (29.4) | 17 (17.0) | 62 (36.7) |
| Glomerulopathies | 69 (7.7) | 53 (8.3) | 16 (6.3) | 16 (5.9) | 6 (6.0) | 10 (5.9) |
| Tubulointerstitial disease | 92 (10.2) | 70 (10.9) | 22 (8.6) | 19 (7.1) | 8 (8.0) | 11 (6.5) |
| Post-AKI | 42 (4.7) | 30 (4.7) | 12 (4.7) | 14(5.2) | 4 (4.0) | 10 (5.9) |
| Other | 58 (6.5) | 42 (6.5) | 16 (6.3) | 18 (6.7) | 6 (6.0) | 12 (7.1) |
| Follow-up, y | 3.2 (2.1) | 2.7 (1.9) | 4.4 (1.9) | 4.4 (1.9) | 3.3 (1.8) | 5.1 (1.6) |
| BMI | 18.3 (3.9) | 18.5 (3.9) | 17.9 (3.7) | 18.2 (3.7) | 18.5 (3.7) | 18.1 (3.8) |
| SDS | 0.07 (1.43) | 0.16 (1.53) | −0.17 (1.09) | −0.07 (1.16) | −0.05 (1.29) | −0.08 (1.08) |
| Height, cm | 140 (21) | 141 (20) | 139 (22) | 142 (22) | 147 (19) | 140 (23) |
| SDS | −1.38 (1.43) | −1.40 (1.40) | −1.31 (1.50) | −1.03 (1.33) | −1.00 (1.21) | −1.04 (1.40) |
| Systolic BP, mm Hg | 113 (15) | 112 (15) | 116 (14) | 114 (14) | 111 (13) | 115.6 (14.3) |
| SDS | 0.73 (1.32) | 0.75 (1.36) | 0.66 (1.20) | 0.53 (1.09) | 0.45 (1.11) | 0.58 (1.08) |
| Diastolic BP, mm Hg | 69 (12) | 69 (12) | 70.8 (12) | 70 (11) | 69 (10) | 71.5 (11.2) |
| SDS | 0.78 (1.14) | 0.65 (1.07) | 1.11 (1.23) | 0.92 (1.06) | 0.56 (0.86) | 1.13 (1.10) |
| suPAR, pg/mL | 6072 (2247) | 6144 (2361) | 5891(1925) | 5205 (1556) | 4638 (1139) | 5541 (1671) |
| eGFR, mL/min/1.73 m2 | 34.0 (15.9) | 28.8 (11.7) | 47.2 (17.3) | 54.1 (11.4) | 48.9 (10.0) | 57.2 (11.0) |
| Proteinuria, No. (%)a | 664 (74.5) | 525 (82.2) | 139 (56.3) | 137 (51.5) | 61 (61.0) | 76 (45.8) |
| Serum cholesterol level, mg/dL | 183 (52) | 181 (52) | 188 (51) | 180 (50) | 173 (49) | 185 (51) |
| Serum albumin level, g/dL | 4.0 (0.6) | 3.9 (0.6) | 4.2 (0.5) | 4.1 (0.5) | 4.0 (0.5) | 4.2 (0.5) |
| Serum bicarbonate level, mEq/L | 21.7 (3.70) | 21.2 (3.8) | 22.7 (3.0) | 23.1 (3.0) | 22.7 (3.2) | 23.3 (2.9) |
Abbreviations: AKI, acute kidney injury; BMI, body mass index, calculated as weight in kilograms divided by height in meters squared; BP, blood pressure; CAKUT, congenital anomalies of the kidneys and urinary tract; eGFR, estimated glomerular filtration rates; SDS, standard deviation score; suPAR, soluble urokinase receptor.SI conversion factor: To convert cholesterol level to millimoles per liter, multiplyby 0.0259; to convert albumin level to grams per liter, multiply by 10; to convert bicarbonate level to millimoles per liter, multiply by 1.
a
Defined by urinary protein excretion level≥0.5 g/g creatinine or urinary albumin excretion level≥50mg/g creatinine.