Table 5.
The Co-Efficient of Drug Interactions (CDI) in MiaPaCa-2 and Panc 05.04 Upon Treatment With ALDH1A1 Specific Inhibitor (A37), in Combination With Gemcitabine, Radiation, and Chemoradiation.
| Co-efficient of drug interactions | |||||
|---|---|---|---|---|---|
| MiaPaCa-2 | |||||
| Treatment | A37 | A37 + Gem | A37 + Rad | A37 + GR | CDI |
| A37 | 18.22 ± 0.35 | ||||
| Gem | 30.94 ± 0.87 | 39.99 ± 0.76 | 0.07094 | ||
| Rad | 40.49 ± 1.27 | 44.27 ± 0.91 | 0.06001 | ||
| GR | 56.08 ± 1.19 | 69.22 ± 1.38 | 0.06774 | ||
| Panc 05.04 | |||||
| Treatment | A37 | A37 + Gem | A37 + Rad | A37 + GR | CDI |
| A37 | 05.68 ± 0.16 | ||||
| Gem | 26.69 ± 3.67 | 40.53 ± 3.01 | 0.26735 | ||
| Rad | 24.99 ± 2.34 | 32.37 ± 1.26 | 0.22805 | ||
| GR | 29.47 ± 0.77 | 36.86 ± 2.06 | 0.22021 | ||
| MiaPaCa-2 3D culture | |||||
| A37 (μM) | Vol. (μm3) | Rad (Gy) | Vol. (μm3) | CDI | |
| 0 | 137,776,090 | 8.5 | 31,224,455 | ||
| 10 | 142,544,081 | 8.5 | 27,296,987 | 6.133E-09 | |
| 20 | 101,913,975 | 8.5 | 17,333,234 | 5.449E-09 | |
| 40 | 58,002,988 | 8.5 | 5,128,585 | 2.837E-09 | |
Calculations
CDI = Survival AB/(Survival A x Survival B).
CDI <1, = 1 or >1 indicates that the drugs are synergistic, additive or antagonistic, respectively.
CDI <0.7 indicates that the drug is significantly synergistic.