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. 2018 Jul 24;19(8):2158. doi: 10.3390/ijms19082158

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Heterogeneous HER2 expression is correlated with a high risk of relapse and resistance to chemotherapy plus trastuzumab in patients with HER2-positive breast cancer. (a) Representative IHC staining of HER2-mono tumors. Scale bar, 250 μm; (b) representative IHC staining of HER2-hetero tumors. Scale bar, 250 μm; (c) PCR rate of HER2-positive breast cancer patients treated with chemotherapy plus trastuzumab (p = 0.29); (d) Disease free survival (DFS) curves of patients with HER2-positive breast cancer after neoadjuvant chemotherapy plus surgery. The median DFS has not been reached (p = 0.97).