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Metronidazole disrupts skeletal muscle RNA epigenetics. Real-time quantitative PCR analysis of RNA m6A methyltransferases Mettl3 and Mettl14 expression in gastrocnemius muscle of metronidazole-treated and nontreated (a) SPF and (b) GF mice. N = 5 mice per group. Data presented as means ± SEM. Asterisks indicate statistically significant differences (*, p < 0.05; ns, nonsignificant with student’s t test).
