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. 2018 Jul 15;59(9):1714–1728. doi: 10.1194/jlr.M087387

Fig. 5.

Fig. 5.

Intervention with citrus flavonoids lowers plasma lipids from baseline. Ldlr−/− mice were fed a HFHC diet for 12 weeks. Subsequently, the same mice were treated with flavonoids added to the HFHC diet for an additional 12 weeks. Mice were fasted for 6 h prior to euthanization. Plasma was subjected to FPLC and lipids were measured in each fraction by enzymatic assay. A: Plasma TGs (n = 19–24 per group). B: Plasma cholesterol (C) (n = 21–24 per group). C: Plasma TG FPLC tracing (n = 6–7 per group). D: Plasma VLDL TG AUC calculations (n = 6–7 per group). E: Plasma cholesterol FPLC tracing (n = 6–7 per group) F: Plasma VLDL cholesterol AUC calculations (n = 6–7 per group). G: Plasma LDL cholesterol AUC calculations (n = 6–7 per group). H: Plasma HDL cholesterol AUC calculations (n = 6–7 per group. Data represent the mean ± SEM. Different letters are statistically different by ANOVA with post hoc Tukey test (P < 0.05). Nar, naringenin; Nob, nobiletin; N.S., not significant.