TABLE 1.
Protective effect of cilastatin of renal function under cisplatin treatment
| Groups | SCreat (mg/dl) | BUN (mg/dl) | GFR (ml/min/100 g) | UVol (ml/24 h) | UProt (mg/24 h) |
| Control | 0.44 ± 0.01 | 16.9 ± 0.9 | 0.46 ± 0.06 | 7 ± 2 | 1.4 ± 0.6 |
| Control + cilastatin | 0.42 ± 0.07 | 17 ± 1 | 0.52 ± 0.08 | 10 ± 1 | 1.65 ± 0.07 |
| Cisplatin | 3 ± 1a | 100 ± 30a | 0.16 ± 0.06a | 24 ± 2a | 6 ± 1b |
| Cisplatin+ cilastatin | 0.6 ± 0.1 | 14 ± 2 | 0.40 ± 0.04 | 10 ± 1 | 1.6 ± 0.3 |
Results are expressed as mean ± SEM. SCreat, serum creatinine; UProt, urinary protein; UVol, urinary volume.
a
P < 0.05 versus other groups (in each column).
b
P < 0.005 versus other groups (in this column).