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The cellular processes during autophagy. The whole dynamic process of autophagosome formation, autophagosome maturation, and autophagosome degradation is termed the “autophagic flux”. (A) In young cells, autophagy efficiently degrades damaged mitochondria or cytosolic proteins. (B) In old cells, lipofuscin occupies the lysosome, which hampers autophagy. Enlarged mitochondria and cytosolic proteins in indigestible aggregates (aggresomes) are increased.
