Table 4. Genotypic drug profile predictions of pan-susceptibility.

Prediction	Genotypic drug profile				Number predicted to have drug profile	Number predicted to have drug profile that are phenotypic ally pansusceptible (%)	Sensitivity %	Specificity %	PPV %	NPV %	Predictions made %
	Inh	Rif	Emb	Pza
(a) Predicted pan-susceptible	S	S	S	S	4,037	3952 (97.9)
(b) Predicted pansusceptible after inferring that 'U' mutations are consistent with susceptibility in this context	S	S	S	U	11	11 (100)
	S	S	U	S	410	399 (97.3)
	S	S	U	U	2	2 (100)
	S	U	S	S	93	88 (94.6)
	S	U	U	S	29	29 (100)
	Total				4,582	4481 (97.8)
(c) Predicted to have some phenotypic resistance	R	S	R or S		397	18 (4.5)
	S	At least one R, no U or F			158	36 (22.8)
	R	R	R or S		1273	1 (0.1)
	Total				1828	55 (3.0)
							95.4	98.6	97.0	97.9	78.0
							94.6	98.8	97.0	97.8	85.1
No prediction made (drug profile prediction incomplete)	U	S or U			150	126 (84.0)
	At least one F, no R				280	240 (85.7)
	At least one R and U, no F				499	6 (1.2)
	At least one R and F, no U				159	3 (1.9)
	At least one R, U, and F				18	0 (0.0)
	Total				1106	375 (33.9)