TABLE 4.

Virulence factor genes from selected E. faecalis strains identified by whole-genome sequencing

Virulence factor function	Gene	Detection of the indicated gene in isolates from:
		Macaque 1 (ST55)			Macaque 2 (ST4)		Macaque 4 (ST48), Nov. 2013	Macaque 3 (ST48), Aug. 2016	Macaque 6 (ST48), Mar. 2017
		Aug. 2011	May 2014	Mar 2015	Aug. 2011	May 2016
Collagen adhesin precursor	ace	+	+	+	+	+	+	+	+
Aggregation substance	agg	−	−	−	+	+	+	+	+
Endocarditis and biofilm-associated pilus genes	ebpA	+	+	+	+	+	+	+	+
	ebpB	+	+	+	+	+	+	+	+
	ebpC	+	+	+	+	+	+	+	+
Cell wall adhesin expressed in serum	efaAfs	+	+	+	+	+	+	+	+
Enterococcal surface protein	esp	+	+	+	+	+	+	+	+
Gelatinase toxin	gelE	−	−	−	+	+	+	+	+
Serine protease	sprE	−	−	−	+	+	+	+	+
Sortase A	srtA	+	+	+	+	+	+	+	+
Quorum-sensing locus	fsrABDC	−	−	−	−	−	+	+	+
Cytolysin (hemolysin-bacteriocin)	cylL	−	−	−	+	+	−	−	−
Posttranslational cytolysin modification	cylM	−	−	−	+	+	−	−	−
Transport of cytolysin	cylB	−	−	−	+	+	−	−	−
Activation of cytolysin	cylA	−	−	−	+	+	−	−	−
Sex pheromone	cad	+	+	+	+	+	+	+	+
Sex pheromone cAM373 precursor	camE	+	+	+	+	+	+	+	+
Sex pheromone	cCF10	+	+	+	+	+	+	+	+
Sex pheromone	cOB1	+	+	+	+	+	+	+	+
Enterococcal Rgg-like regulator	elrA	+	+	+	+	+	+	+	+
Hyaluronidase	hylA	+	+	+	+	+	+	+	+
	hylB	+	+	+	−	−	+	+	+
Thiol peroxidase	tpx	+	+	+	+	+	+	+	+