Table 3.

Dose-effect relationship parameters for treatment by two-drug combinations of 122.4 with etoposide or cisplatinor doxorubicin. BS-24-1 cells were treated with the two-drug combinations. Potency, shape (sigmoidicity) and conformity of dose-effect curve (linear correlation coefficient) are represented by Dm, m, and r, respectively, where Dm (ED50) is the antilog of x-intercept in µg/mL, m is the slope of the median-effect plot signifying the shape of the dose-effect curve (m = 1, >1 and <1 indicates hyperbolic, sigmoidal and negative sigmoidal curve, respectively), and r is the linear correlation coefficient of the median-effect plot. Data shown are pooled results of minimum of three experiments.

Drug	Dm	M	r
Etoposide	0.0383	1.185	0.919
Cisplatin	6.32533	0.555	0.945
Doxorubicin	0.049	2.754	0.966