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. 2018 Aug 16;19(8):2422. doi: 10.3390/ijms19082422

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The G. uralensis flavonoids induce the amounts of melanin content, tyrosinase activity, and tyrosinase expression of B16-F10 melanoma cells. (A) B16-F10 cells were treated with indicated concentrations of selected flavonoids (GF-1, 4, 6, and 9) or with α-MSH at 20 nM for 48 h. The amounts of melanin (left panel) and tyrosinase activity (right panel) were determined. (B) The level of tyrosinase protein (~91 kDa) in the melanoma cells was measured by Western blot (left panel). The amount of tyrosinase was qualified against GAPDH (~37 kDa) (right panel). Data are expressed as percentage of control, in means ± SEM (n = 3). * p < 0.05, ** p < 0.01, compared with control.