Table 2.
Influence of 12 weeks of RET in n = 3 individuals with BTHS
| Measure | Pre-training | Post-training | P-value |
|---|---|---|---|
| VO2peak (mL/kg/min) | 9.9 (2.3) | 9.3 (1.02) | 0.72 |
| Max work rate (W) | 50 (9) | 51 (6) | 0.80 |
| Max HR (bpm) | 146 (19) | 155 (13) | 0.55 |
| Max ventilation (L/min) | 36.6 (3.2) | 39.7 (4.3) | 0.37 |
| Max RER | 1.4 (0.2) | 1.5 (0.1) | 0.47 |
| MNLWHF total score | 11 (8.2) | 19 (9.5) | 0.18 |
| Arm lean (kg) | 1.7 (0.2) | 1.8 (0.3) | 0.38 |
| Leg lean (kg) | 5.5 (0.2) | 5.7 (0.2) | 0.32 |
| Trunk lean (kg) | 18.3 (1.3) | 18.5 (1.6) | 0.58 |
| Whole-body fat (kg) | 22.2 (3.0) | 22.4 (2.2) | 0.73 |
| Whole-body lean (kg) | 36.0 (1.9) | 36.4 (1.9) | 0.10 |
| Skeletal muscle index (%) | 29.1 (0.0) | 28.1 (0.3) | 0.45 |
| Body weight (kg) | 60.5 (1.9) | 61.7 (1.1) | 0.22 |
| Arm BMD (g/cm2) | 0.59 (0.03) | 0.61 (0.03) | 0.09 |
| Leg BMD (g/cm2) | 0.90 (0.10 | 0.96 (0.13) | 0.47 |
| Thoracic spine BMD (g/cm2) | 0.65 (0.08) | 0.63 (0.07) | 0.15 |
|
Lumbar spine BMD (g/cm2) Pelvic BMD (g/cm2) |
0.80 (0.07) 0.91 (0.14) |
0.83 (0.13) 0.97 (0.15) |
0.14 0.10 |
| Resting HR (bpm) | 77 (8) | 78 (6) | 0.77 |
| Resting SBP (mmHg) | 94 (2) | 102 (14) | 0.52 |
| Resting DBP (mmHg) | 60 (1) | 58 (6) | 0.56 |
| LVM 2D | 136 (27) | 126 (51) | 0.29 |
| Ejection fraction (%) | 51 (31) | 48 (23) | 0.72 |
| Fractional shortening (%) | 26 (10) | 30 (16) | 0.33 |
| E/A | 1.9 (0.8) | 1.8 (0.3) | 0.79 |
| Global strain (%) | −14 (7) | −15 (6) | 0.23 |
| Creatinine (mg/dL) | 0.6 (0.1) | 0.6 (0.1) | 0.59 |
| Glucose (mg/dL) | 96.5 (17) | 96.3 (3.1) | 0.37 |
| HCT (%) | 39.6 (2.1) | 40.5 (1.8) | 0.89 |
| ANC (cells/mm3) | 0.7 (0.5) | 1.6 (7) | 0.06 |
| Total CK (U/L) | 62 (12.2) | 61 (15) | 0.73 |
| BNP (pg/mL) | 35 (16.1) | 44 (26.7) | 0.69 |
Values are mean (SD)
RER respiratory exchange ratio, MNLWHF Minnesota Living with Heart Failure questionnaire, HR heart rate, SBP systolic blood pressure, DBP diastolic blood pressure, LVM 2D left ventricular mass measured by 2-dimensional echocardiography, E/A early to late filling ratio, HCT hematocrit, ANC absolute neutrophil count, CK creatine kinase, BNP brain natriuretic peptide