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. 2018 May 25;54(3):35. doi: 10.3390/medicina54030035

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© 2018 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Proposed schematic diagram explains possible mechanism of action of depigmenting agents on zebrafish embryo depigmentation. Zebrafish embryo chorion had a specific nanoporosity on the external membrane (500–700 µM in diameter) [37,38]. Chorion, organized as a three-layered structure (i.e., extraembryonic mesoderm), with four major polypeptides (i.e., N-linked glycoproteins) [37,95,96]. Moreover, hydrophobic molecules and at slow rate very small uncharged polar molecules can diffuse via lipid bilayer. The passive diffusion rate through a membrane is proportional to the LogP of the molecules between the membrane (lipophilic milieu) and the external medium (aqueous environment). Denotes symbols: , depigmenting agent; , inhibition; , downregulation.

Inline graphic — Proposed schematic diagram explains possible mechanism of action of depigmenting agents on zebrafish embryo depigmentation. Zebrafish embryo chorion had a specific nanoporosity on the external membrane (500–700 µM in diameter) [37,38]. Chorion, organized as a three-layered structure (i.e., extraembryonic mesoderm), with four major polypeptides (i.e., N-linked glycoproteins) [37,95,96]. Moreover, hydrophobic molecules and at slow rate very small uncharged polar molecules can diffuse via lipid bilayer. The passive diffusion rate through a membrane is proportional to the LogP of the molecules between the membrane (lipophilic milieu) and the external medium (aqueous environment). Denotes symbols: , depigmenting agent; , inhibition; , downregulation.