Table 3.
Comparison of allele and genotype frequencies of two MAOA gene polymorphisms in the ADHD combined subtype and controls.
| Allele/Genotype | ADHD-C a Boys (n = 52) | Control Boys (n = 191) | p-Value b | OR (95% CI) | |
|---|---|---|---|---|---|
| Rs6323 | G | 34 (65.4%) | 102 (53.4%) | 0.123 | 0.61 (0.321–1.149) |
| T | 18 (34.6%) | 89 (46.6%) | |||
| uVNTR | 3.5R | 34 (65.4%) | 109 (58.0%) | 0.335 | 0.73 (0.385–1.386) |
| 4.5R | 18 (34.6%) | 79 (42.0%) | |||
| Allele/genotype | ADHD-C a girls (n = 26) | Control girls (n = 131) | p-value b | OR (95% CI) | |
| Rs6323 | G | 30 (57.7%) | 152 (58.0%) | 1.000 | 1.01 (0.555–1.851) |
| T | 22 (42.3%) | 110 (42.0%) | |||
| G/G | 6 (23.1%) | 48 (36.7%) | - | Reference | |
| G/T | 18 (69.2%) | 56 (42.7%) | 0.058 | 2.57 (0.945–6.998) | |
| T/T | 2 (7.7%) | 27 (20.6%) | 0.535 | 0.59 (0.112–3.143) | |
| p-value b | 0.033 * | 0.161 | |||
| Dominant | G/G | 6 (23.1%) | 48 (36.6%) | 0.183 | 0.52 (0.195–1.381) |
| G/T+T/T | 20 (76.9%) | 83 (63.4%) | |||
| Recessive | G/G+G/T | 24 (92.3%) | 104 (79.4%) | 0.121 | 0.32 (0.071–1.443) |
| T/T | 2 (7.7%) | 27 (20.6%) | |||
| Over-dominant | G/G+T/T | 8 (31.8%) | 75 (57.2%) | 0.013 * | 3.01 (1.223–7.426) |
| G/T | 18 (69.2%) | 56 (42.8%) | |||
| uVNTR | 3.5R | 22 (44.0%) | 150 (59.5%) | 0.031 * | 1.87 (1.014–3.453) |
| 4.5R | 28 (56.0%) | 102 (40.5%) | |||
| 3.5R/3.5R | 3 (12.0%) | 48 (38.1%) | - | Reference | |
| 3.5R/4.5R | 16 (64.0%) | 54 (42.9%) | 0.009 * | 4.74 (1.301–17.273) | |
| 4.5R/4.5R | 6 (24.0%) | 24 (19.0%) | 0.050 | 4.00 (0.920–17.397) | |
| p-value b | 0.135 | 0.214 | |||
| Dominant | 3.5R/3.5R | 3 (12.0%) | 48 (38.1%) | 0.011 * | 4.51 (1.282–15.889) |
| 3.5R/4.5R+4.5R/4.5R | 22 (88.0%) | 78 (61.9%) | |||
| Recessive | 3.5R/3.5R+3.5R/4.5R | 19 (76.0%) | 102 (81.5%) | 0.571 | 1.34 (0.484–3.721) |
| 4.5R/4.5R | 6 (24.0%) | 24 (19.1%) | |||
| Over-dominant | 3.5R/3.5R+4.5R/4.5R | 9 (36.0%) | 72 (57.1%) | 0.053 | 2.37 (0.974–5.770) |
| 3.5R/4.5R | 16 (64.0%) | 54 (42.9%) |
Inattentive (I) and Hyperactive-Impulsive (HI) subtypes were not analyzed due to the small sample size. * p < 0.05. a Combined subtype. b Uncorrected chi-square or Fisher’s test, as appropriate. c Hardy-Weinberg equilibrium p-value. The samples who have 2.5 or 5.5 repeats of uVNTR were excluded because of the small sample size.