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. 2018 Jul 4;16(3):1685–1692. doi: 10.3892/etm.2018.6406

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Copyright: © Al-Shboul et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 7. — Effect of blockade of NO synthase and sGC on estrogen-induced relaxation in GSMCs from female rats. Cells were treated with ACh and contraction was expressed relative to control-cell contraction. ACh induced GSMC contraction, whereas pre-treatment of the GSMCs with E2 significantly reduced ACh-induced contraction. Relaxation induced by E2 was significantly inhibited in muscle cells pre-incubated with ODQ or L-NNA. Cumulative data (n=50 cells from 10 female rats) are presented as the mean ± standard error of the mean. *P<0.05 vs. ACh; ^€P<0.05 vs. ACh+E2. NO, nitric oxide; sGC, soluble guanylyl cyclase; GSMC, gastric smooth muscle cells; ACh, acetylcholine; E2, 17β-estradiol; ODQ, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one; L-NNA, Nω-nitro-L-arginine.