Table I.
Gene ontology analysis of upregulated and downregulated genes in sorafenib-resistant HCC.
| A, Upregulated expression | ||||
|---|---|---|---|---|
| Category | Term | Count | % | P-value |
| GOTERM_CC_DIRECT | GO:0005615/extracellular space | 110 | 16.492 | <0.001 |
| GOTERM_CC_DIRECT | GO:0070062/extracellular exosome | 177 | 26.537 | <0.001 |
| GOTERM_CC_DIRECT | GO:0005576/extracellular region | 100 | 14.993 | <0.001 |
| GOTERM_CC_DIRECT | GO:0072562/blood microparticle | 21 | 3.148 | <0.001 |
| GOTERM_CC_DIRECT | GO:0016021/integral component of membrane | 235 | 35.232 | <0.001 |
| GOTERM_BP_DIRECT | GO:0010951/negative regulation of endopeptidase activity | 18 | 2.699 | <0.001 |
| GOTERM_BP_DIRECT | GO:0042632/cholesterol homeostasis | 13 | 1.949 | <0.001 |
| GOTERM_BP_DIRECT | GO:0042730/fibrinolysis | 8 | 1.199 | <0.001 |
| GOTERM_BP_DIRECT | GO:0002576/platelet degranulation | 15 | 2.249 | <0.001 |
| GOTERM_BP_DIRECT | GO:0030198/extracellular matrix organization | 20 | 2.999 | <0.001 |
| GOTERM_MF_DIRECT | GO:0005518/collagen binding | 11 | 1.649 | <0.001 |
| GOTERM_MF_DIRECT | GO:0005102/receptor binding | 29 | 4.348 | <0.001 |
| GOTERM_MF_DIRECT | GO:0004252/serine-type endopeptidase activity | 24 | 3.598 | <0.001 |
| GOTERM_MF_DIRECT | GO:0001948/glycoprotein binding | 10 | 1.499 | <0.001 |
| GOTERM_MF_DIRECT | GO:0008131/primary amine oxidase activity | 4 | 0.600 | <0.001 |
| Extracellular space means GO enrichment of cellular primarily enriches in the extracellular space. | ||||
| B, downregulated expression | ||||
| Category | Term/gene function | Count | % | P-value |
| GOTERM_MF_DIRECT | GO:0044822/poly(A) RNA binding | 99 | 18.099 | <0.001 |
| GOTERM_MF_DIRECT | GO:0004386/helicase activity | 20 | 3.656 | <0.001 |
| GOTERM_MF_DIRECT | GO:0005524/ATP binding | 89 | 16.271 | <0.001 |
| GOTERM_MF_DIRECT | GO:0004004/ATP-dependent RNA helicase activity | 14 | 2.559 | <0.001 |
| GOTERM_MF_DIRECT | GO:0008026/ATP-dependent helicase activity | 9 | 1.645 | <0.001 |
| GOTERM_CC_DIRECT | GO:0005730/nucleolus | 75 | 13.711 | <0.001 |
| GOTERM_CC_DIRECT | GO:0005654/nucleoplasm | 152 | 27.788 | <0.001 |
| GOTERM_CC_DIRECT | GO:0005813/centrosome | 43 | 7.861 | <0.001 |
| GOTERM_CC_DIRECT | GO:0005634/nucleus | 199 | 36.380 | <0.001 |
| GOTERM_CC_DIRECT | GO:0005814/centriole | 16 | 2.925 | <0.001 |
| GOTERM_BP_DIRECT | GO:0006260/DNA replication | 25 | 4.570 | <0.001 |
| GOTERM_BP_DIRECT | GO:0006281/DNA repair | 27 | 4.936 | <0.001 |
| GOTERM_BP_DIRECT | GO:0000732/strand displacement | 10 | 1.828 | <0.001 |
| GOTERM_BP_DIRECT | GO:0000731/DNA synthesis involved in DNA repair | 11 | 2.011 | <0.001 |
| GOTERM_BP_DIRECT | GO:0006974/cellular response to DNA damage stimulus | 23 | 4.205 | <0.001 |
BP, biological process; CC, cellular component; MF, molecular function; GO, gene ontology.