Table II.

KEGG pathway analysis of upregulated and downregulated genes in sorafenib-resistant hepatocellular carcinoma.

A, Upregulated genes
Name	Gene count	%	P-value	Genes
hsa04610: Complement and coagulation cascades	20	2.999	<0.001	KNG1, F12, F10, CFB, C3, C1R, SERPING1, F7, C1S, C8B, FGG, FGB, SERPINF2, KLKB1, SERPINA5, SERPIND1, C2, CFI, PLAU, F2R
hsa04142: Lysosome	14	2.099	0.003047	TCIRG1, CTSZ, CLTB, ACP5, ACP2, CTSA, CTSS, CTSL, LAPTM5, TPP1, ARSA, CTSE, SMPD1, CTSD
hsa04931: Insulin resistance	13	1.949	0.003298	SREBF1, NR1H2, PPP1R3C, PPP1R3B, SOCS3, SLC2A2, PRKAG2, PRKAB2, NFKBIA, CREB3L3, SLC27A3, CPT1A, PCK1
hsa01100: Metabolic pathways	74	11.094	0.006009	TM7SF2, ALAD, OGDHL, ADH1C, ADH1A, AGXT, CKB, PTGIS, P4HA2, ST3GAL5, MAT1A, RGN, DAO, ITPK1, AGPAT3, AGPAT2, GATM, ACADS, SPTLC3, FAXDC2, PISD, PNPLA3, PMM1, ALDH3B1, DGAT2, CYP27A1, HAO2, EXT1, AOC1, AKR1D1, LCT, AOC3, ACAA1, GALNT2, ENPP7, ASS1, HSD17B2, ALDOC, ENPP3, CERS4, PLPP3, PIPOX, THTPA, B3GNT5, DHCR7, PLA2G12B, PEMT, HAAO, ENO3, ETNK2, FUT2, BDH1, GAL3ST1, ACSL5, CYP19A1, TCIRG1, MOGAT3, ST6GAL1, NDUFA2, SI, MAOB, HOGA1, AMPD3, IDNK, PCK1, POLD4, BAAT, HMGCS2, SMPD1, LIPC, PHYKPL, PON3
hsa04975: Fat digestion and absorption	7	1.049	0.007472	APOA4, ABCG8, MOGAT3, DGAT2, PLA2G12B, PLPP3, AGPAT2
B, Downregulated genes
Name	Gene count	%	P-value	Genes
hsa03008: Ribosome biogenesis in eukaryotes	17	3.108	<0.001	XPO1, GTPBP4, UTP6, UTP15, GNL3L, BMS1, DROSHA, WDR36, POP1, WDR3, NOP58, GNL2, MDN1, RBM28, SPATA5, WDR43, GNL3
hsa03013: RNA transport	17	3.108	<0.001	XPOT, XPO1, XPO5, ALYREF, EIF5B, NUPL2, NUP155, PNN, TRNT1, UPF3B, SEH1L, NUP205, POP1, EIF3J, RANBP2, TPR, GEMIN5
hsa03460: Fanconi anemia pathway	9	1.645	<0.001	FANCM, BLM, FANCD2, FANCI, BRCA2, BRIP1, ATR, FANCA, BRCA1
hsa04742: Taste transduction	7	1.280	<0.001	TAS2R13, TAS2R14, TAS2R19, TAS2R46, TAS2R43, TAS2R20, TAS2R10
hsa04110: Cell cycle	9	1.645	0.014438	CDC7, CDC6, RBL1, PRKDC, ATR, MYC, CDC25A, ATM, STAG1

KEGG, Kyoto Encyclopedia of Genes and Genomes.