Table 2.
General features of the studies
| Studies | No of patients in the DDC group (n) | No of patients in control group (n) | Year of patients’ enrollment | Type of study | Type of participants |
|---|---|---|---|---|---|
| CURRENT OASIS 7 | 8560 | 8703 | 2006–2009 | RCT | ACS + PCI |
| OPTIMUS2007 | 20 | 20 | – | Pilot study | DM + CAD |
| Khatri2013 | 26 | 64 | 2009–2010 | Retrospective study | CAD |
| OPTIMUS3 | 35 | 34 | 2008–2009 | RCT | DM + CAD |
| PRINCIPLE TIMI 44 | 99 | 102 | – | RCT | Any CAD with planned PCI |
| Tailor2014 | 52 | 54 | 2010–2012 | RCT | CAD + ACS |
| Chen2017 | 50 | 57 + 46 | 2012–2014 | OC | CAD |
| Wu2017 | 20 | 20 | 2014–2015 | RCT | CAD with planned PCI |
| ACCEL AMI | 30 | 30 + 30 | – | RCT | AMI |
| ACCEL DM | 39 | 41 | – | RCT | DM + AMI undergoing PCI |
| CREATIVE | 359 | 362 + 355 | 2012–2015 | RCT | CAD + PCI |
| Ha2013 | 21 | 21 | – | RCT | DM + PCI |
| HOST ASSURE | 1876 | 1879 | 2010–2011 | RCT | CAD + PCI |
| Jeong2009 | 30 | 30 | – | RCT | CAD + PCI |
| Total number of patients (n) | 11,217 | 11,848 |
Abbreviations: ACS: acute coronary syndrome, PCI: percutaneous coronary intervention, DM: diabetes mellitus, CAD: coronary artery disease, AMI: acute myocardial infarction, RCT: randomized controlled trials, OC: observational studies; DDC: double dose clopidogrel