Fig. 6.

Significant decrease in promoter activity without hypermethylated fragments in GSTP1/ TXNRD2 genes. (A) Diagrams of the full-length promoter and shortened promoter without hypermethylated fragments of GSTP1 and TXNRD2. (B) Luciferase reporter assay results showed that transcription activity of GSTP1 and TXNRD2 promoter was significantly decreased without DNA fragments, including hypermethylated CpG units found in Sequenom MassARRAY. n = 3 independent experiments, mean ± SD, unpaired two-tailed Student's t-test, ****P < 0.0001.