Fig. 3.

Effect of AVV2/8-DYRK1A gene transfer on brain DYRK1A and CBS activity level. A) DYRK1A protein level, and B) CBS activity in brain of Cbs^+/- mice with intermediate hhcy with (hhcy/AAV) or without (hhcy) AAV2/8-DYRK1A treatment, and control (CTL) mice. Brain DYRK1A was determined by slot blotting, and values were obtained by normalization of images from DYRK1A to total proteins colored with Ponceau-S. Data were normalized to the mean of CTL mice. The results are represented as means ± SEM. n = number of mice.