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RAPA significantly decreases the (A) proliferation and (B) migration of human umbilical vein endothelial cells. Magnification, ×100. VEGF, MMP-2 and MMP-9 expression levels were significantly decreased following treatment with RAPA at the (C) mRNA and (D) protein level. **P<0.01 vs. Control group. RAPA, rapamycin; VEGF, vascular endothelial growth factor; MMP, matrix metalloproteinase; OD, optical density.
