Figure 5.

Silencing of TUG1 attenuates rapamycin-induced inhibition of (A) proliferation and (B) migration of human umbilical vein endothelial cells. Magnification, ×100. VEGF, MMP-2 and MMP-9 expression levels were evaluated at the (C) mRNA and (D) protein level. *P<0.05 and **P<0.01 vs. the siNC group. RAPA, rapamycin; VEGF, vascular endothelial growth factor; MMP, matrix metalloproteinase; OD, optical density; si, small interfering RNA; TUG1, taurine upregulated 1 (non-protein coding); NC, negative control.