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. 2018 Sep 3;6:85. doi: 10.1186/s40425-018-0400-4

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Histology of metastasis and organizing pneumonia. a, b Wedge resection of the lung after immunotherapy. The melanoma metastasis shows excellent response to treatment with extensive regressive necrosis. (HE, original magnification 25× and 200×, respectively). Here only melanin pigment and necrosis with lack of vital tumor cells are present. c, d Distant to the necrotic metastasis circumscribed areas of immunotherapy-induced organizing pneumonia with intraalveolar fibromyxoid proliferations and mild lymphoplasmacytic inflammation (HE original magnification 12,5× and 200×, respectively). (e) Immunhistochemical analysis of CD3⁺ cells in inflammatory lesions (200× magnification). f, g Staining of CD4⁺ (f) and CD8⁺ (g) cells (200× magnification). h Staining for FOXP3⁺ regulatory T cells in inflammatory lesions (200× magnification). i Immunostaining for PD-L1 in inflammatory lesions (100× magnification, SP-263 clone)