Table 1.
Main characteristics of the eligible studies
| Study | Country | Recruitment period | No. of patients | Age (years) | Gender (m/f) | Follow-up (months) | Study design | Survival analysis | Surgery |
|---|---|---|---|---|---|---|---|---|---|
| Xia et al.2017 [12] | China | 2005–2007 | 293 | Median (range) 55 (15–86) |
90/203 | Median (range) 99.1 (2.63–120.47) |
Retrospective | OS,PFS | nephrectomy |
| Wu et al.2017 [13] | China | 2004–2012 | 301 | Median (range) 53 (4–83) |
206/95 | Median (range) 51.6 (3–121) |
Retrospective | OS | nephrectomy |
| Niu et al.2017 [14] | China | 2008–2009 | 384 | Mean ± SD 53.9 ± 14.9 |
273/111 | Median (range) 73 (42–74) |
Retrospective | OS,RFS | RN and PN |
| Kim et al.2017 [15] | Korea | 2006–2012 | 177 | Mean ± SD 62 ± 10.9 |
136/41 | Median (range) 19.2 (0.2–63.8) |
Retrospective | OS,PFS | nephrectomy |
| Gu et al.2017 [16] | China | 2006–2014 | 184 | Mean ± SD 54.3 ± 13 |
142/42 | Mean ± SD 23.3 ± 14.6 |
Retrospective | OS, PFS | nephrectomy |
| Gershman et al.2017 [17] | USA | 1980–2010 | 138 | Mean (range) 63 (54–72) |
91/47 | Median (IQR) 102(67.2–130.8) |
Retrospective | CSS, OS | RN and PN |
| Chen et al.2017 [18] | China | 2006–2015 | 172 | Mean ± SD 56.5 ± 12.4 |
123/40 | Mean ± SD 34.4 ± 22.9 |
Retrospective | CSS,RFS | RN |
| Chang1 et al.2016 [19] | China | 2008–2014 | 233 | Median (IQR) 56(48–62) |
170/63 | Median (IQR) 68(41–71) |
Retrospective | RFS | nephrectomy |
| Volpe et al.2016 [3] | Italy | 2000–2010 | 308 | Median (IQR) 65(57–73) |
110/80 | Median (IQR) 72(39–108) |
Retrospective | CSS | RN |
| Khor et al.2016 [20] | USA | 1985–2003 | 842 | Median(range) 61.5(22.4–89) |
527/315 | Median (range) 73.2 (0.12–273.6) |
Retrospective | OS | RN and PN |
| NguyenHoang et al.2016 [21] | China | 2008–2009 | 392 | Mean ± SD 55.2 ± 12.1 |
116/276 | Median (range) 73 (39–74) |
Retrospective | OS, RFS | RN and PN |
| Errarte et al.2016 [22] | Spain | NA | 59 | Mean (range) 59 (25–83) |
45/14 | Mean (range) 65 (1–240) |
Retrospective | OS | nephrectomy |
| Byun et al.2016 [23] | Korea | 2000–2014 | 1284 | Mean ± SD 55.9 ± 12.9 |
913/371 | Median (IQR) 39(19–69) |
Retrospective | CSS | RN and PN |
| Huang et al.2015 [24] | China | 1991–2011 | 218 | Mean ± SD 58.9 ± 12.2 |
169/49 | Median (IQR) 43(17.8–67.5) |
Retrospective | RFS | RN and PN |
| Cornejo et al.2015 [25] | USA | 1984–2010 | 154 | Mean (range) 62.7 (26–86) |
125/29 | Mean (range) 73.9 (0.13–222) |
Retrospective | CSS, OS | RN and PN |
| Teng et al.2014 [26] | China | 2004–2009 | 378 | Mean ± SD 53.4 ± 12.4 |
272/106 | Median (range) 60 (2–97) |
Retrospective | CSS, RFS | RN and PN |
| Park et al.2014 [27] | Korea | 2006–2011 | 83 | Mean ± SD 56.3 ± 10.5 |
60/23 | Median (range) 18 (1–62) |
Retrospective | OS, PFS | RN and PN |
| Oliveira et al.2014 [28] | Brazil | 1988–2006 | 94 | Mean ± SD 59.7 ± 12.3 |
67/27 | Median 11.7 |
Retrospective | CSS | RN and PN |
| Can et al.2014 [29] | Turkey | 1995–2012 | 127 | Mean (range) 56 (26–80) |
70/57 | Mean (range) 46 (3–169) |
Retrospective | CSS | RN and PN |
| Pichler et al.2013 [30] | Austria | 2000–2010 | 994 | Mean ± SD 63.2 ± 11.9 |
599/395 | Mean (range) 48.1 (0–132) |
Retrospective | CSS, OS | RN and PN |
| Kruck et al.2013 [31] | Germany | 1993–2006 | 278 | Mean ± SD 62.2 ± 12.5 |
194/84 | Median (IQR) 65(20–100) |
Retrospective | CSS, OS | RN and PN |
| Fukatsu et al.2013 [32] | Japan | 1986–2008 | 561 | Median(range) 60(21–89) |
442/119 | Median (range) 55.7 (1–246) |
Retrospective | CSS | nephrectomy |
| Sukov et al.2013 [33] | USA | 1970–2002 | 395 | Median(range) 65(25–89) |
327/68 | NA | Retrospective | CSS | RN and PN |
| Chang2 et al.2011 [34] | China | 2001–2006 | 328 | Mean (range) 59.2 (23–89) |
216/112 | Mean (range) 46.5 (1.0–97.2) |
Retrospective | OS | RN and PN |
| Leibovich et al.2010 [35] | USA | 1970–2003 | 3062 | NA | 2,0160/1002 | Median (range) 97.2 (0–432) |
Retrospective | CSS | RN and PN |
| Katz et al.2010 [36] | USA | 1989–2004 | 586 | Median 61 |
530/311 | Median (range) 61 (1–209) |
Retrospective | CSS, OS | RN and PN |
| Roos et al.2009 [37] | Germany | 1990–2006 | 118 | Mean (range) 64.5 (37.8–84.9) |
76/42 | Median (range) 3.2 (0.3–16.1) |
Retrospective | CSS, PFS | nephrectomy |
| Coons et al.2009 [38] | USA | 1988–2006 | 128 | Median(range) 64(35–87) |
95/33 | Median (range) 25.2 (0–124) |
Retrospective | CSS, OS, RFS | nephrectomy |
| Pflanz et al.2008 [39] | Germany | 1992–2006 | 607 | Mean (range) 61.6 (18–84) |
387/220 | Median 54 |
Retrospective | CSS, OS | RN and PN |
| Lee et al.2006 [40] | Korea | 1993–2003 | 485 | Median(range) 55(26–81) |
360/125 | Median(range) 50.9(1–148.6) |
Retrospective | CSS | RN and PN |
| Lam et al.2005 [41] | USA | 1989–2000 | 311 | Median(range) 62(27–89) |
208/103 | Median (range) 45 (0.3–117) |
Retrospective | CSS | nephrectomy |
| Tornberg et al.2016 [42] | Finland | 2006–2014 | 142 | Median(range) 65(41–89) |
95/47 | Median (range) 31 (0–111) |
Prospective | CSS | RN and cytoreductive |
| Schiavina et al.2015 [43] | Italy | 2000–2013 | 185 | Mean ± SD 63.3 ± 11.8 |
149/36 | Median (IQR) 32(18–62) |
Prospective | CSS | RN and PN |
| Ramsey et al.2008 [44] | UK | 2001–2005 | 83 | NA | 50/33 | Median 38 |
Prospective | CSS, RFS | nephrectomy |
total numbers rows:36; SD standard deviation, NA data not applicable, CSS cancer-specific survival, OS overall survival, RFS recurrence-free survival, PFS progression-free survival, RD radical nephrectomy, PN partial nephrectomy