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. Author manuscript; available in PMC: 2018 Sep 4.
Published in final edited form as: Bioconjug Chem. 2017 Aug 10;28(9):2429–2439. doi: 10.1021/acs.bioconjchem.7b00421

Figure 4. Cellular uptake and cytotoxicity of peptide−drug conjugates in the SW480 model.

Figure 4

(a) Cellular uptake of oxali-Pt−Y-1 or oxali-Pt−succ by SW480 and SW480 ITGB6 high cells. Cells were incubated with 50 μM of either drug for 3 h before isolation and measurement by ICP-MS. The experiment was performed in triplicate. (b) Cytotoxicity of 10 μM oxali-Pt−Y-1, oxali-Pt−succ, and oxaliplatin after long-term exposure (14 days) to SW480, SW480 ITGB6 low, and SW480 ITGB6 high cells. Cell viability was measured by crystal violet staining from duplicates of three independent experiments. Values given in panels a and b are the mean ± standard deviation, and significances were established using one-way ANOVA with Bonferroni’s multiple comparison test (***, p ≤ 0.001; **, p ≤ 0.01, and *, p ≤ 0.05).