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. Author manuscript; available in PMC: 2019 May 25.
Published in final edited form as: Circ Res. 2018 May 25;122(11):1576–1585. doi: 10.1161/CIRCRESAHA.118.311585

Figure 2.

Figure 2.

U-shape of the multivariable-adjusted relation between baseline serum 25(OH)D3 levels and incident cardiovascular events reported by Wang et al. (from Circulation 117:503–511, with permission [pending]). Solid lines show the estimated relation of adjusted hazard ratios (with 95% confidence limits) and 25(OH)D3 levels when time to cardiovascular event is modeled as a function of penalized regression splines of 25(OH)D3 levels with adjustment for all other covariates. Hatched lines on the horizontal axis represent cardiovascular events (top axis) and individuals (bottom axis). This relationship suggests increased cardiovascular risk at both low and high levels.