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. 2018 Sep 4;18:148. doi: 10.1186/s12890-018-0715-4

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Hierarchical clustering analysis of the TNF-signaling pathway. SAECs and NHBEs were exposed to 2.5% CSE for 24 h or not (controls). Two different batches of SAECs and NHBEs were used. The specific cluster containing genes upregulated by CSE exposure predominantly in SAECs is highlighted (right). High relative expression is indicated in green, and low relative expression is indicated in red. CSE, cigarette smoke extract; SAECs, small airway epithelial cells; NHBEs, normal human bronchial epithelial cells.