Table 2.
Overrepresented terms in SAECs by GO enrichment analysis
| GO term | p | Genes |
|---|---|---|
| Inflammatory response | < 0.001 | CCL20, SPP1, PTGS2, IL1F9, IL1B, BMP2, TLR2, FOS, ELF3, CYP4F11, IL24, IL8 |
| Response to vitamin D | < 0.001 | SPP1, PLA2G4A, PTGS2, IL1B |
| Response to hypoxia | < 0.001 | SOD2, MUC1, IL1B, CYP1A1, BMP2, ALDH3A1, TLR2 |
| Positive regulation of fever generation | 0.001 | PLA2G4A, PTGS2, IL1B |
| Wound healing | 0.001 | EREG, CCL20, IL1B, IL24, SERPINB2 |
| Response to lipopolysaccharide | 0.002 | SOD2, PLA2G4A, CCRN4L, PTGS2, CYP1A1, FOS |
| Ovulation | 0.002 | EREG, PTGS2, IL1B |
| Aging | 0.003 | NQO1, PLA2G4A, IL1B, CYP1A1, ALDH3A1, FOS |
| Cellular response to organic cyclic compound | 0.004 | IL1B, CYP1A1, BMP2, CYP1B1 |
| Positive regulation of apoptotic process | 0.004 | ALDH1A3, NR4A1, PLA2G4A, PTGS2, IL1B, BMP2 |
| Decidualization | 0.005 | SPP1, PLA2G4A, PTGS2 |
| Positive regulation of NF-κB import into nucleus | 0.005 | PTGS2, IL1B, TLR2 |
| Epithelial cell differentiation | 0.005 | DHRS9, MUC1, AKR1C1, ELF3 |
| Arachidonic acid metabolic process | 0.007 | CYP4F12, PLA2G4A, CYP1B1 |
| Positive regulation of vascular endothelial growth factor production | 0.007 | PTGS2, IL1B, CYP1B1 |
| Response to immobilization stress | 0.007 | SOD2, CYP1A1, FOS |
| Transcription from RNA polymerase II promoter | 0.012 | OVOL1, NFYC, ATF3, CCRN4L, PIR, FOSB, FOS, ELF3 |
| Negative regulation of cell cycle | 0.013 | NR4A1, PTGS2, BMP2 |
| Apoptotic process | 0.019 | NCF1, NR4A1, IL1B, MAP3K8, TLR2, TRAF1, MAL, IL24 |
| Positive regulation of transcription from RNA polymerase II promoter | 0.019 | NFYC, NR4A1, ATF3, FOSB, MYO6, CSF3, IL1B, BMP2, TLR2, FOS, ELF3 |
| Embryo implantation | 0.019 | SPP1, PTGS2, IL1B |
| Positive regulation of nitric oxide biosynthetic | 0.019 | SOD2, PTGS2, IL1B |
| Cellular response to lipopolysaccharide | 0.023 | CCL20, CSF3, IL24, IL8 |
| Response to progesterone | 0.024 | FOSB, TLR2, FOS |
| Skeletal muscle cell differentiation | 0.024 | NR4A1, ATF3, FOS |
| Response to cAMP | 0.027 | FOSB, ALDH3A1, FOS |
| Cell-cell signaling | 0.033 | EREG, CCL20, IL1F9, IL1B, BMP2 |
| Positive regulation of gene expression | 0.034 | PRDM1, ID1, IL1B, BMP2, TLR2 |
| Neutrophil chemotaxis | 0.040 | CCL20, IL1B, IL8 |
SAECs small airway epithelial cells, GO gene ontology