Table 2.
Parameter estimates from the pharmacokinetic model describing mefloquine
| Parameter value (%RSE)ab | 95% CIb | IIV %CV (%RSE)ab | 95% CIb | Shrinkage (%)a | |
|---|---|---|---|---|---|
| CL/F (l/h) | 2.77 (4.81) | 2.52–3.04 | 38.0 (14.8) | 27.1–48.0 | 33.7 |
| Vc/F (l) | 359 (3.38) | 335–384 | – | – | – |
| MTT (h) | 3.89 (5.18) | 3.54–4.32 | 43.6 (11.5) | 33.7–53.0 | 18.5 |
| Q/F (l/h) | 11.7 (8.37) | 10.1–13.9 | 55 (27.3) | 22.4–80.5 | 50.8 |
| Vp/F (l) | 474 (8.02) | 406–554 | 63.1 (15.5) | 43.9–81.7 | 43.2 |
| σ2 | 0.0902 (18.7) | 0.0591–0.124 | – | – | 17.9 |
σ2 is the variance of the residual error. %RSE is the relative standard error calculated as 100 × median/(standard error). CV% is calculated as 100 × SQRT (EXP(ω2) − 1). The 2.5th and 97.5th percentiles are used to present the 95% CI (95% confidence interval)
CL/F, apparent elimination clearance; Vc/F, apparent volume of distribution of the central compartment; MTT, mean transit time of the absorption; Q/F, apparent inter-compartmental clearance; Vp/F, apparent volume of distribution of the peripheral compartment; F, relative bioavailability
aFrom NONMEM
bFrom bootstrap run with 958 successful runs (out of 1000)