Table 3.

Secondary parameters for mefloquine

	Cured infection median (min–max) (n = 93)	Recrudescent infection median (min–max) (n = 36)	p-values
Cmax (ng/ml)	2050 (1290–2410)	1980 (1280–2370)	0.0107
Tmax (h)	7.54 (3.76–18.2)	7.50 (4.92–16.6)	0.832
AUC0–150days (µg*h/ml)	450 (144–731)	455 (227–831)	0.554
t1/2 (days)	9.72 (1.97–16.7)	10.3 (5.58–17.9)	0.0449

C_max, maximum concentration; T_max, time to reach the maximum concentration; AUC_0–150days, area under the concentration–time curve from the first dose to day 150 after the first dose; t_1/2, terminal elimination half-life. P-values were calculated using an unpaired t test