Table 1.

Characteristics of Patients With Tularemia Treated With Tetracyclines

Patient	Age	Sex	Year/Month of Diagnosis	Type of Tularemia	Diagnosis	Prior Antibiotic Therapy	Delay Before Tetracycline Therapy	Tetracycline Used/Duration of Therapy	Surgical Procedurea	Outcome
1	62	F	1988/November	Ulceroglandular	Single serology	Cephalexin, ceftriaxone	28 days	Tetracycline/10 days	Aspiration	Cure/no relapse
2	8	M	1991/June	Ulceroglandular	Single serology	Cephalexin, erythromycin	14 days	Doxycycline/21 days	Aspiration	Cure/no relapse
3	66	F	1994/August	Glandular	Single serology	None	Unknown	Doxycycline/28 days	Incision and drainageb	Cure/no relapse
4	76	F	1995/August	Ulceroglandular	Single serology	Clarithromycin, amoxicillin/ clavulanic acid	28 days	Doxycycline/28 days	Incision and drainage	Cure/no relapse
5	42	M	1995/August	Glandular	Single serology	Unknown	21 days	Doxycycline/21 days	None	Cure/no relapse
6	37	M	1996/May	Ulceroglandular	Culture	Cloxacillin	10 days	Doxycycline/42 days	Aspirationc	Cure/no relapse
7	36	F	2000/May	Glandular	Culture	Cephalexin, clindamycin	21 days	Doxycycline/21 days	Incision and drainaged	Cure/no relapse
8	9	F	2001/May	Glandular	Single serology	Amoxicillin, cephalexin	28 days	Doxycycline/21 days	Aspiration	Cure/no relapse
9	46	M	2002/June	Typhoidal	Single serology	Amoxicillin/clavulanic acid	21 days	Doxycycline/14 days	None	Cure/no relapse
10	77	F	2002/July	Ulceroglandular	Single serology	None	56 days	Doxycycline/14 days	None	Cure/no relapse
11	91	F	2010/April	Oculoglandular	Culture	Vancomycin, ceftriaxone, metronidazole	7 days	Doxycycline/10 days	None	Cure/no relapse
12	19	M	2011/October	Glandular	Single serology	None	42 days	Doxycycline/14 days	Aspiration	Cure/no relapse
13	32	M	2012/August	Typhoidal	Single serology	None	Unknown	Doxycycline/21 days	None	Cure/no relapse
14	31	M	2012/August	Typhoidal	Single serology	None	Unknown	Doxycycline/21 days	None	Cure/no relapse
15	44	F	2013/January	Glandular	Single serology	Azithromycin	84 days	Doxycycline/14 days	None	Cure/no relapse
16	72	M	2014/October	Ulceroglandular	Single serology	Cephalexin, ceftriaxone, TMP-SMX	7 days	Doxycycline/21 days	Incision and drainage	Cure/no relapse
17	11	M	2015/August	Glandular	Single serology	Amoxicillin/clavulanic acid, cephalexin	10 days	Doxycycline/14 days	None	Cure/no relapse

Abbreviations: F, female; M, male; SMX, sulfamethoxazole; TMP, trimethoprim.

^aInitial procedures done before initiation of tetracycline or doxycycline therapy.

^bRequired repeat incision and drainage on day 14 of doxycycline.

^cRequired repeat aspiration on day 14 of doxycycline.

^dRequired aspiration on day 7 of doxycycline and incision and drainage on day 14 of doxycycline.