Table 3. GOs that exhibited significant concentration-dependent alterations among the ASD-related GOs suggested by previous studies.
| Category | Chang et al. (2015)a) | Jasien et al. (2014)b) | Term | p-value | |
|---|---|---|---|---|---|
| Cortical | Hippocampal | ||||
| BP | GO:0003001 | GO:0003001 | generation of a signal involved in cell-cell signalling | 3.0e-5 | |
| BP | GO:0003008 | system process | 2.1e-11 | ||
| BP | GO:0006325 | chromatin organization | 2.3e-4 | ||
| BP | GO:0006810 | transport | 9.5e-7 | ||
| BP | GO:0006836 | neurotransmitter transport | 6.2e-5 | ||
| BP | GO:0006875 | cellular metal ion homeostasis | 4.6e-4 | ||
| BP | GO:0007187 | sarcolemma | 1.0e-6 | ||
| BP | GO:0007188 | adenylate cyclase-modulating G-protein coupled receptor signalling pathway | 2.6e-6 | ||
| BP | GO:0007267 | cell-cell signalling | 1.0e-4 | ||
| BP | GO:0007268 | GO:0007268 | synaptic transmission | 7.4e-6 | |
| BP | GO:0007613 | memory | 1.6e-4 | ||
| BP | GO:0016477 | cell migration | 3.5e-5 | ||
| BP | GO:0019226 | transmission of nerve impulse | 4.1e-5 | ||
| BP | GO:0023061 | signal release | 3.0e-5 | ||
| BP | GO:0030030 | cell projection organization | 5.0e-4 | ||
| BP | GO:0030705 | cytoskeleton-dependent intracellular transport | 7.7e-4 | ||
| BP | GO:0030799 | regulation of cyclic nucleotide metabolic process | 3.1e-4 | ||
| BP | GO:0030802 | regulation of cyclic nucleotide biosynthetic process | 2.7e-4 | ||
| BP | GO:0030808 | regulation of nucleotide biosynthetic process | 2.7e-4 | ||
| BP | GO:0030814 | regulation of cAMP metabolic process | 1.4e-4 | ||
| BP | GO:0030817 | regulation of cAMP biosynthetic process | 1.2e-4 | ||
| BP | GO:0032940 | secretion by cell | 1.7e-6 | ||
| BP | GO:0035637 | multicellular organismal signalling | 2.2e-4 | ||
| BP | GO:0040029 | regulation of gene expression, epigenetic | 2.8e-4 | ||
| BP | GO:0044707 | single-multicellular organism process | 8.1e-4 | ||
| BP | GO:0046903 | secretion | 1.3e-6 | ||
| BP | GO:0048870 | cell motility | 1.6e-5 | ||
| BP | GO:0050877 | neurological system process | 5.6e-13 | ||
| BP | GO:0051179 | localization | 1.2e-5 | ||
| BP | GO:0051234 | establishment of localization | 4.8e-7 | ||
| BP | GO:0051674 | localization of cell | 1.6e-5 | ||
| BP | GO:0055065 | metal ion homeostasis | 9.1e-4 | ||
| BP | GO:0055082 | cellular chemical homeostasis | 2.9e-4 | ||
| BP | GO:0065008 | regulation of biological quality | 4.6e-6 | ||
| BP | GO:0071944 | cell periphery | 2.6e-16 | ||
| CC | GO:0000785 | chromatin | 1.1e-7 | ||
| CC | GO:0005623 | cell | 5.0e-4 | ||
| CC | GO:0005737 | cytoplasm | 2.3e-5 | ||
| CC | GO:0005829 | cytosol | 4.0e-5 | ||
| CC | GO:0005856 | cytoskeleton | 4.9e-5 | ||
| CC | GO:0016023 | cytoplasmic membrane-bounded vesicle | 1.4e-4 | ||
| CC | GO:0031410 | cytoplasmic vesicle | 2.0e-4 | ||
| CC | GO:0031982 | vesicle | 9.1e-5 | ||
| CC | GO:0031988 | membrane-bounded vesicle | 9.3e-5 | ||
| CC | GO:0032991 | macromolecular complex | 3.2e-5 | ||
| CC | GO:0042995 | cell projection (at 72 h) | 7.2e-4 | ||
| CC | GO:0042995 | cell projection (at 120 h) | 6.0e-4 | ||
| CC | GO:0043226 | organelle | 1.8e-4 | ||
| CC | GO:0043229 | intracellular organelle | 1.7e-4 | ||
| CC | GO:0044444 | cytoplasmic part | 7.2e-7 | ||
| CC | GO:0044446 | intracellular organelle part | 4.9e-7 | ||
| CC | GO:0044456 | GO:0044456 | synapse part | 2.7e-5 | |
| CC | GO:0045202 | GO:0045202 | synapse | 7.0e-7 | |
| CC | GO:0070161 | anchoring junction | 1.6e-5 | ||
| CC | GO:0070469 | respiratory chain | 2.7e-4 | ||
| MF | GO:0003824 | catalytic activity | 4.1e-5 | ||
| MF | GO:0004713 | protein tyrosine kinase activity | 6.3e-4 | ||
| MF | GO:0005216 | ion channel activity | 5.0e-4 | ||
| MF | GO:0005244 | voltage-gated ion channel activity | 3.2e-5 | ||
| MF | GO:0005261 | cation channel activity | 6.9e-4 | ||
| MF | GO:0015078 | hydrogen ion transmembrane transporter activity | 3.5e-4 | ||
| MF | GO:0015276 | ligand-gated ion channel activity | 1.5e-6 | ||
| MF | GO:0019905 | syntaxin binding | 1.6e-4 | ||
| MF | GO:0022832 | voltage-gated channel activity | 4.0e-5 | ||
| MF | GO:0022834 | ligand-gated channel activity | 1.5e-6 | ||
| MF | GO:0022836 | gated channel activity | 9.9e-6 | ||
| MF | GO:0022838 | substrate-specific channel activity | 5.8e-5 | ||
| MF | GO:0022843 | voltage-gated cation channel activity | 5.7e-5 | ||
| MF | GO:0046873 | metal ion transmembrane transporter activity | 1.0e-5 | ||
a) List of GOs related to human ASD from Chang et al. (2015).
b) List of GOs in the aged BTBR mouse model from Jasien et al. (2014). GO enrichments from multiple studies are marked in bold.