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. 2018 Aug 22;14(8):e1007266. doi: 10.1371/journal.ppat.1007266

Fig 1. NLRC3 deficiency promotes activation of CD4+ T in M. tuberculosis infection.

Fig 1

WT and Nlrc3-/- mice were infected with M. tuberculosis and mice were harvested at 3 weeks post-infection (w.p.i.). (A) Lung cells were restimulated with M. tuberculosis lysate directly ex vivo and the intracellular production of IFN-γ and TNF-α by CD4+ T cells was determined. Pooled data are presented in the right panel. (B) Expression of activation markers by lung CD4+ T cells. (C) Concentration of IFN-γ, TNF-α and GM-CSF in lungs (homogenized in 2 ml PBS and 0.05% Tween 80) as detected by ELISA. Data shown in (A, C) are the mean ±SD. **P < 0.01 and ***P < 0.001. Data are representative of three independent experiments with similar results.