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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: J Hepatol. 2017 Jul 17;67(5):1009–1017. doi: 10.1016/j.jhep.2017.05.023

Fig. 5. Dantrolene attenuates GLuc-SERCaMP and endogenous SERCaMP.

Fig. 5

(A, B) Dantrolene decreases GLuc-SERCaMP and endogenous SERCaMP release during ad lib access to high fat pellets. Rats were administered dantrolene (15mg/kg) or vehicle for 7 days during diet (mean ± SEM, n=6 rats/group, *p<0.05, 2-way ANOVA, Sidak’s multiple comparison test). (C) Decreased food consumption among dantrolene injected rats (mean ± SEM, n=6 rats/group, ****p<0.0001, 2-way ANOVA). (D) Dantrolene decreases BiP mRNA levels in liver tissue (data expressed as fold change (2^-ΔΔCt) relative to vehicle-treated rats (mean ± upper and lower limits (2ΔΔCt±SD), n=6 rats/group, multiple t-test, Holm-Sidak method (dantrolene versus vehicle) transformed from ΔCt±SD, *p=0.01).