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. 2018 Aug 29;13:4869–4880. doi: 10.2147/IJN.S166769

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© 2018 Guo et al. This work is published and licensed by Dove Medical Press Limited

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The growth inhibition effect of GEM-HSA-NP on BxPC-3 and SW1990 cell lines.

Notes: Cell viability was measured at 0, 24, 48, 72 and 96 h after BxPC-3 cells (A) and SW1990 cells (B) were treated with 0.05 μg/mL GEM, 0.1 μg/mL GEM-C14 (which is equivalent of 0.05 μg/mL GEM), 2.083 μg/mL (which is equivalent of 0.05 μg/mL GEM) or 20.83 μg/mL GEM-HSA-NP, with or without 1 μM NBMPR (an inhibitor of hENT1). (C) Quantitative analysis of the cell proliferation in each group of BxPC-3 cell line. *A significant difference compared with the GEM + NBMPR group. (D) Quantitative analysis of the cell proliferation in each group of SW1990 cell line.

Abbreviations: GEM, gemcitabine; GEM-C14, 4-N-myristoyl-gemcitabine; GEM-HSA-NP, gemcitabine-loaded human serum albumin nanoparticle; NBMPR, S-(4-nitrobenzyl)-6-thioinosine.