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. 2018 Aug 29;13:4869–4880. doi: 10.2147/IJN.S166769

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© 2018 Guo et al. This work is published and licensed by Dove Medical Press Limited

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The effect of GEM-HSA-NP on cell apoptosis.

Notes: (A) The apoptosis rates in BxPC-3 cells analyzed by flow cytometry after cells were treated with 0.05 μg/mL GEM, 0.1 μg/mL GEM-C14 and 2.083 μg/mL GEM-HSA-NP for 48 h, with or without 1μM NBMPR. (B) Apoptosis rates in each group of BxPC-3 cell line. (C) The apoptosis rates in SW1990 cells analyzed by flow cytometry after cells were treated with 0.05 μg/mL GEM, 0.1 μg/mL GEM-C14 and 2.083 μg/mL GEM-HSA-NP for 48 h, with or without 1μM NBMPR. (D) Apoptosis rates in each group of SW1990 cell line.

Abbreviations: 7-AAD, 7-aminoactinomycin D; GEM, gemcitabine; GEM-C14, 4-N-myristoyl-gemcitabine; GEM-HSA-NP, gemcitabine-loaded human serum albumin nanoparticle; NBMPR, S-(4-nitrobenzyl)-6-thioinosine.