Table 3. Changes in NaChBac gating parameters induced by 4 µM 4-fluoropropofol.

NaChBac mutant	Activation			Inactivation
	ΔV1/2	ΔZ		ΔV1/2	ΔZ
	mV	e0		mV	e0
WT	−14.11 ± 1.87§§§	0.24 ± 0.32		−10.96 ± 0.80§§§	−0.78 ± 0.21
V40C	−14.33 ± 1.20§§§	0.29 ± 0.35		−10.56 ± 1.51§§	−0.28 ± 0.32
S129C	−6.76 ± 2.37§	−0.17 ± 0.08		−3.73 ± 3.49*	0.20 ± 0.81
T189C	−15.77 ± 1.92§§	0.80 ± 0.14§		−8.61 ± 2.02§	−0.78 ± 0.26
F227C	−6.58 ± 3.11	−0.26 ± 0.18		−17.30 ± 1.29§§§	−4.80 ± 0.58§§,***

Values are given as mean ± SEM (n = 4–13). Control versus 4-fluoropropofol for each mutant, evaluated by paired t test: ^§, P < 0.05; ^§§, P < 0.01; ^§§§, P < 0.001. Change induced by 4-fluoropropofol in NaChBac WT versus in each mutant, evaluated by one-way ANOVA with Bonferroni post hoc correction: *, P < 0.05; ***, P < 1E-4.