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. 2018 Sep 1;30(3):193–205. doi: 10.5792/ksrr.17.067

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Copyright © 2018 Korean Knee Society

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 3 — Transcriptome-wide differential gene expression and pathway enrichment in the comparison of anterior cruciate ligament-mesenchymal stem cells (ACL-MSCs) from young and old donors. Using a microarray, 561 probesets were found to be upregulated in the cells from young donors, while 613 probesets were upregulated in cells from old donors. (A) The top 10 differentially expressed probesets are demonstrated as a heat map. (B) The corresponding genes enriched several terms in the GO biological process, biological function, and cellular component ontologies. Those enriched by the genes upregulated in ACL-MSCs from young donors mainly enriched pathways related to protein dephosphorylation and components of the cytoskeleton (B). Those enriched by the genes upregulated in ACL-MSCs from old donors were mainly related to nuclear transport, protein kinase B activity, epithelial-mesenchymal cell signaling, and the activity of RNA polymerase II cofactor. (C) Gene expression for BMP4 was higher in ACL-MSCs from old donors than in ACL-MSCs from young donors.