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. 2018 Sep 3;215(9):2397–2412. doi: 10.1084/jem.20172225

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© 2018 Qian et al.

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Figure 3. — Lung epithelial cells from Aoah^−/− mice have defective innate responses to HDM. (A) Aoah^+/+ or Aoah^−/− mice were instilled i.n. with HDM and 5 h later, cytokine/chemokine levels were measured in BALF using ELISA. Data were combined from three experiments. n = 6–9. (B) 5 h after HDM instillation, cytokine/chemokine mRNA were measured in lung homogenates using qPCR. Data were combined from two experiments. n = 6–8. (C) TLR signaling negative regulators Tnfaip3, SHIP, IRAK-M, and SOCS-1 mRNA levels were measured in lung homogenates. Data were combined from two experiments. n = 6–8. (D) 5 h after instillation of HDM, lung epithelial cells were sorted by using flow cytometry, and cytokine/chemokine mRNA were measured using qPCR. Data were combined from two experiments. n = 6–8. (E) Tnfaip3, SHIP, IRAK-M, and SOCS-1 mRNA levels were measured in sorted lung epithelial cells. Data were combined from two experiments. n = 6–8. (A–E) Mann-Whitney test was used. *, P < 0.05; **, P < 0.01; ***, P < 0.001.