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. 2018 Sep 3;215(9):2397–2412. doi: 10.1084/jem.20172225

Figure 6.

Figure 6.

Preexposure to LPS injected s.c. inhibits allergic asthma. (A) Aoah+/+ mice were injected with 50 µg of LPS s.c. 24 and 48 h later, TLR4-stimulating activities were measured in their plasma. Data were combined from two experiments. n = 12. (B) Aoah+/+ mice were treated with LPS s.c. 6, 4, and 2 d before HDM sensitization. (C) Cells in BALF were analyzed on day 14. Data were combined from two experiments. n = 6. (D) BALF cytokine levels were measured on day 14 using ELISA. Data were combined from two experiments. n = 6. (E) AHR was measured on day 14. n = 4. (F) Mice were pretreated with LPS s.c. and then were sensitized with HDM on days 0, 1, and 2. Lung DC numbers were measured on day 4. n = 5. (G) Mice were pretreated with LPS s.c. and then were instilled with HDM; 5 h later, their BALF cytokines were measured. n = 5. (A, C, D, F, and G) Mann-Whitney test was used. (E) Two-way ANOVA was used. *, P < 0.05; **, P < 0.01; ***, P < 0.001.