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. 2018 Sep 3;215(9):2413–2428. doi: 10.1084/jem.20171810

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© 2018 Deason et al.

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Figure 4. — BCAP deficiency does not affect steady-state Th1 and Th17 differentiation. (A) Representative flow plots (left) and quantification (right) of IL-17A and IFN-γ in CD4⁺CD44⁺ T cells isolated from spleens, peripheral lymph nodes, mesenteric lymph nodes, and lamina propria of BCAP^fl/fl and BCAPΔT mice. Shown is the mean ± SEM, n = 3 for spleen, peripheral lymph nodes, and mesenteric lymph nodes, and n = 8 for lamina propria. Statistical analysis was performed with the two-tailed unpaired Student’s t test. (B) qPCR analysis of several genes in BCAP^fl/fl and BCAPΔT naive CD4⁺ T cells polarized for indicated time points to Th17 + IL-1β, relative to their expression in BCAP^fl/fl T cells polarized in neutralizing conditions. Shown is the mean ± SD; n = 4. *, P < 0.05; **, P < 0.01. Statistical analysis was performed with the two-tailed unpaired Student’s t test.