Table 3.
Clinical characteristics, nerve function data and statistical data in 92 Japanese diabetes patients
| Clinical characteristics and averaged nerve function data | Mean ± SD | |||||
|---|---|---|---|---|---|---|
| Sex (male/female) | 59/33 | |||||
| Age (years) | 65.7 ± 7.0 | |||||
| Height (cm) | 161.7 ± 9.15 | |||||
| Weight (kg) | 63.8 ± 13.8 | |||||
| Body mass index (m/kg2) | 24.2 ± 3.97 | |||||
| HbA1c (NGSP) (%) | 7.04 ± 1.13 | |||||
| Amp (μV) | 10.8 ± 5.46 | |||||
| CV (m/s) | 50.8 ± 5.29 | |||||
| VT (dB) | 22.0 ± 8.6 | |||||
| Prevalence of neurological symptoms and signs, ‘probable DSPN’ | ||||||
| Positive neuropathic sensory symptoms | 19/92 (20.7%) | |||||
| Unequivocally decreased or absent ankle reflexes | 32/92 (34.8%) | |||||
| Symmetric decrease of distal sensation (abnormal VT) | 10/92 (10.9%) | |||||
| Probable diabetic symmetrical sensorimotor polyneuropathy (‘probable DSPN’) | 14/92 (15.2%) | |||||
| Prevalence of nerve conduction abnormalities (NCA1, NCA2) judged by JRF or USRF | ||||||
| JRF | USRF | P‐values | ||||
| Bilaterally abnormal Amp | 14/92 (15.2%) | 8/92 (8.70%) | 0.1728 | |||
| Bilaterally abnormal CV | 15/92 (16.3%) | 14/92 (15.2%) | 0.8397 | |||
| NCA1 (one or more abnormal value of Amp and CV) | 23/92 (25.0%) | 18/92 (19.6%) | 0.3757 | |||
| NCA2 (two abnormal values of Amp and CV | 6/92 (6.50%) | 4/92 (4.35%) | 0.5154 | |||
| Sensitivity, specificity and reproducibility of the predictively of diagnosing ‘probable DSPN’ by the each NCAs based on JRF or USRF | ||||||
| RF | USRF | |||||
| Sensitivity | Specificity | Kappa coefficient (P‐values) | Sensitivity | Specificity | Kappa coefficient (P‐values) | |
| NCA1 | 85% | 86% | 0.57 (<0.001) | 71% | 90% | 0.55 (<0.001) |
| NCA2 | 43% | 100% | 0.56 (<0.001) | 29% | 100% | 0.40 (<0.001) |
The χ2‐test and Cohen's kappa coefficient method were used for statistical analysis. Nerve action potential amplitude of the sural nerve (Amp) and conduction velocity of the sural nerve (CV) were measured by a point‐of‐care nerve conduction device – DPNCheck®. VT, quantitative vibration threshold at 125 Hz at the big toe tips using the vibratory sensation meter (AU‐02B®). JRF, regression formulas representing the cut‐off value of normal limit in Japanese participants calculated by the quantile regression method; NGSP, National Glycohemoglobin Standardization Program; SD, standard deviation; USRF, regression formulas representing the cut‐off value of normal limit in USA participants.