Table 1.
Six micro‐ribonucleic acid‐binding single‐nucleotide polymorphisms and the Hardy–Weinberg equilibrium test
| SNP | Gene | Main function | Min/Maj | Chr. position | MAF (CHB)† | Sample MAF | Predicted binding miRNA | Algorithm | P |
|---|---|---|---|---|---|---|---|---|---|
| rs712699 | PAX4 | Pancreatic development | A/G | Chr.7:127250597 | 0.356 | 0.403 | hsa‐miR‐223 | TargetScan;MiRDB | 0.122 |
| rs1051295 | KCNB1 | Insulin secretion | C/T | Chr.20:47988905 | 0.444 | 0.413 | hsa‐miR‐216a | PolymiRTS;TargetScan | 0.485 |
| rs1042842 | MFN2 | Mitochondrial fusion | A/G | Chr.1: 12071680 | 0.376 | 0.397 | hsa‐miR‐183 | PolymiRTS;TargetScan | 0.116 |
| rs1050800 | LPIN1 | Adipocyte differentiation | T/C | Chr.2: 11965814 | 0.211 | 0.256 | hsa‐miR‐96 | PolymiRTS;TargetScan | 0.727 |
| rs1802295 | VPS26A | Transport proteins | T/C | Chr.10:70931474 | 0.108 | 0.116 | hsa‐miR‐510 | PolymiRTS;TargetScan;MiRDB | 0.861 |
| rs10802502 | NLRP3 | Regulate inflammation | C/T | Chr.1: 247612295 | 0.423 | 0.484 | hsa‐miR‐548 | PolymiRTS;TargetScan;microRNA.org | 0.074 |
†From 1,000‐genome database. CHB, Chinese Han in Beijing; Chr., chromosome; MAF, frequency of minor allele; Maj, major allele; Min, minor allele; miRNA, micro‐ribonucleic acid.