Table 2. The association of lncRNA polymorphisms and hepatocellular risk stratified by host characteristics.
| Variables | Genotype | HCC compared with CON | P | OR (95% CI) |
|---|---|---|---|---|
| H19 rs2735971 | ||||
| Gender | ||||
| Male | GG | 276/248 | 1 (Ref.) | |
| AG | 93/117 | 0.048 | 0.72 (0.52–1.00) | |
| AA | 9/9 | 0.791 | 0.88 (0.34–2.26) | |
| Female | GG | 51/65 | 1 (Ref.) | |
| AG | 33/22 | 0.058 | 1.92 (0.98–3.78) | |
| AA | 3/4 | 0.804 | 0.82 (0.17–4.05) | |
| Age | ||||
| ≤60 | GG | 205/230 | 1 (Ref.) | |
| AG | 87/102 | 0.811 | 0.96 (0.68–1.35) | |
| AA | 8/7 | 0.537 | 1.35 (0.48–3.81) | |
| >60 | GG | 122/83 | 1 (Ref.) | |
| AG | 39/37 | 0.160 | 0.68 (0.40–1.17) | |
| AA | 4/6 | 0.216 | 0.44 (0.12–1.62) | |
| Smoking | ||||
| Ever smoker | GG | 56/80 | 1 (Ref.) | |
| AG | 19/43 | 0.105 | 0.58 (0.30–1.12) | |
| AA | 3/4 | 0.952 | 1.05 (0.23–4.89) | |
| Never smoked | GG | 152/128 | 1 (Ref.) | |
| AG | 62/62 | 0.357 | 0.81 (0.53–1.26) | |
| AA | 7/6 | 0.886 | 1.09 (0.33–3.63) | |
| Alcohol drinking | ||||
| Drinker | GG | 32/57 | 1 (Ref.) | |
| AG | 11/33 | 0.171 | 0.57 (0.25–1.28) | |
| AA | 3/1 | 0.157 | 5.39 (0.52–55.55) | |
| Non-drinker | GG | 175/151 | 1 (Ref.) | |
| AG | 70/71 | 0.413 | 0.84 (0.56–1.27) | |
| AA | 7/9 | 0.485 | 0.68 (0.24–1.98) | |
| H19 rs2839698 | ||||
| Gender | ||||
| Male | CC | 176/195 | 1 (Ref.) | |
| CT | 168/152 | 0.191 | 1.22 (0.91–1.65) | |
| TT | 33/24 | 0.147 | 1.52 (0.86–2.68) | |
| Female | CC | 39/50 | 1 (Ref.) | |
| CT | 43/33 | 0.092 | 1.74 (0.91–3.30) | |
| TT | 7/8 | 0.729 | 1.23 (0.39–3.91) | |
| Age | ||||
| ≤60 | CC | 135/185 | 1 (Ref.) | |
| CT | 143/125 | 0.007 | 1.57 (1.13–2.18) | |
| TT | 25/25 | 0.276 | 1.40 (0.78–2.55) | |
| >60 | CC | 80/60 | 1 (Ref.) | |
| CT | 68/60 | 0.528 | 0.86 (0.53–1.39) | |
| TT | 15/7 | 0.320 | 1.63 (0.62–4.27) | |
| Smoking | ||||
| Ever smoker | CC | 29/65 | 1 (Ref.) | |
| CT | 40/50 | 0.041 | 1.89 (1.03–3.48) | |
| TT | 9/10 | 0.155 | 2.08(0.76–5.68) | |
| Never smoked | CC | 112/105 | 1 (Ref.) | |
| CT | 88/78 | 0.917 | 1.02 (0.67–1.55) | |
| TT | 22/12 | 0.121 | 1.88 (0.85–4.16) | |
| Alcohol drinking | ||||
| Drinker | CC | 19/45 | 1 (Ref.) | |
| CT | 22/40 | 0.402 | 1.39 (0.65–2.97) | |
| TT | 5/4 | 0.088 | 3.68 (0.82–16.46) | |
| Non-drinker | CC | 121/124 | 1 (Ref.) | |
| CT | 106/88 | 0.360 | 1.20 (0.81–1.76) | |
| TT | 26/18 | 0.166 | 1.61 (0.82–3.15) | |
| H19 rs3024270 | ||||
| Gender | ||||
| Male | GG | 129/136 | 1 (Ref.) | |
| CG | 181/173 | 0.573 | 1.10 (0.80–1.51) | |
| CC | 71/64 | 0.452 | 1.17 (0.77–1.78) | |
| Female | GG | 22/34 | 1 (Ref.) | |
| CG | 44/42 | 0.092 | 1.86 (0.90–3.82) | |
| CC | 24/17 | 0.051 | 2.39 (1.00–5.73) | |
| Age | ||||
| ≤60 | GG | 93/128 | 1 (Ref.) | |
| CG | 145/157 | 0.153 | 1.40 (0.88–2.21) | |
| CC | 67/56 | 0.019 | 1.71 (1.09–2.68) | |
| >60 | GG | 58/42 | 1 (Ref.) | |
| CG | 80/58 | 0.151 | 1.29 (0.91–1.84) | |
| CC | 28/25 | 0.438 | 0.76 (0.39–1.51) | |
| Smoking | ||||
| Ever smoker | GG | 17/44 | 1 (Ref.) | |
| CG | 44/57 | 0.055 | 1.96 (0.99–3.89) | |
| CC | 18/24 | 0.122 | 1.93 (0.84–4.42) | |
| Never smoked | GG | 74/69 | 1 (Ref.) | |
| CG | 100/94 | 0.802 | 0.94 (0.60–1.48) | |
| CC | 50/36 | 0.310 | 1.34 (0.76–2.34) | |
| Alcohol drinking | ||||
| Drinker | GG | 13/26 | 1 (Ref.) | |
| CG | 23/48 | 0.921 | 0.96 (0.41–2.22) | |
| CC | 10/16 | 0.553 | 1.37 (0.48–3.93) | |
| Non-drinker | GG | 77/87 | 1 (Ref.) | |
| CG | 121/102 | 0.186 | 1.33 (0.87–2.01) | |
| CC | 58/44 | 0.099 | 1.53 (0.92–2.55) |
Abbreviation: CI, confidence interval. The bold text means the significant results.