Table 5. Univariate and multivariate cox proportional hazard analysis for H19 SNPs on HCC prognosis.
| Variables | All HCC, n (%) | Deaths, n | MSTa (M) | Univariate P-value | Hazard ratio (95% CI) | Multivariatec P-value | Hazard ratio (95% CI) | ||
|---|---|---|---|---|---|---|---|---|---|
| n=286 | n=156 | ||||||||
| H19 | rs2735971 | GG | 193 (67.48) | 117 (75) | 47.000 | 1 (Ref.) | 1 (Ref.) | ||
| AG | 85 (29.72) | 37 (23.72) | 52.000 | 0.769 | 1.06 (0.72–1.57) | 0.752 | 0.94 (0.64–1.39) | ||
| AA | 8 (2.80) | 2 (1.28) | 33.000 | 0.756 | 1.12 (0.55–2.26) | 0.763 | 0.80 (0.20–3.30) | ||
| n=344 | n=136 | ||||||||
| rs2839698 | CC | 182 (52.9) | 69 (50.7) | 56.000 | 1 (Ref.) | 1 (Ref.) | |||
| CT | 144 (41.9) | 61 (44.9) | 48.000 | 0.776 | 0.95 (0.67–1.34) | 0.716 | 1.07 (0.75–1.51) | ||
| TT | 18 (5.2) | 6 (4.4) | 78.4b | 0.501 | 1.16 (0.76–1.76) | 0.499 | 0.75 (0.32–1.73) | ||
| n=349 | n=137 | ||||||||
| rs3024270 | GG | 59 (16.9) | 21 (15.3) | 90.000 | 1 (Ref.) | 1 (Ref.) | |||
| CG | 159 (45.6) | 67 (48.9) | 48.000 | 0.716 | 0.91 (0.56–1.49) | 0.887 | 1.03 (0.71–1.49) | ||
| CC | 131 (37.5) | 49 (35.8) | 56.000 | 0.831 | 0.97 (0.75–1.26) | 0.808 | 0.94 (0.56–1.58) |
a, MST, median survival time (months).
b, Mean survival time was provided when MST could not be calculated.
c, Multivariate survival analysis was carried out by adding the age and gender variable to the clinicopathological parameters with P<0.05.