Table 6. Univariate proportional hazard analysis stratified by host characteristics for the association of H19 polymorphisms and HCC.
| Gene | SNP | Stratified | Stratified factors | Genotype | HCC (n (%)) | Deaths (n) | MSTa(M) | P-value | Hazard ratio (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
| H19 | rs2735971 | ||||||||
| Gender | Male | GG | 160 (69.57) | 67 | 47.0 | 1 (Ref.) | |||
| AG | 64 (27.83) | 28 | 52.0 | 0.669 | 0.91 (0.58–1.41) | ||||
| AA | 6 (2.60) | 2 | 33.0 | 0.778 | 1.23 (0.30–5.04) | ||||
| Female | GG | 33 (58.93) | 13 | 38.0 | 1 (Ref.) | ||||
| AG | 21(37.50) | 9 | 32.0 | 0.918 | 1.05 (0.45–2.45) | ||||
| AA | 2 (3.57) | 0 | NA | NA | NA | ||||
| Age | ≤60 | GG | 109 (63.01) | 43 | 47.0 | 1 (Ref.) | |||
| AG | 58 (33.53) | 28 | 48.0 | 0.599 | 1.14 (0.71–1.83) | ||||
| AA | 6 (3.46) | 1 | 25.8b | 0.844 | 0.82 (0.11–6.03) | ||||
| >60 | GG | 84 (74.34) | 37 | 45.0 | 1 (Ref.) | ||||
| AG | 27 (23.89) | 9 | 56.0 | 0.276 | 0.67 (0.32–1.38) | ||||
| AA | 2 (1.77) | 1 | 33.0 | 0.847 | 0.82 (0.11–6.02) | ||||
| Smoking | Ever smoker | GG | 17 (62.96) | 6 | 97.1b | 1 (Ref.) | |||
| AG | 8 (29.63) | 1 | 117.2b | 0.264 | 0.30 (0.04–2.49) | ||||
| AA | 2 (7.41) | 0 | NA | NA | NA | ||||
| Never smoked | GG | 99 (66.44) | 35 | 81.3b | 1 (Ref.) | ||||
| AG | 46 (30.87) | 20 | 32.0 | 0.702 | 1.11 (0.64–1.93) | ||||
| AA | 4 (2.69) | 1 | 33.0 | 0.665 | 0.65 (0.09–4.72) | ||||
| Alcohol drinking | Drinker | GG | 9 (60.00) | 2 | NA | 1 (Ref.) | |||
| AG | 4 (26.67) | 0 | NA | NA | NA | ||||
| AA | 2 (13.33) | 0 | NA | NA | NA | ||||
| Non-drinker | GG | 107 (66.46) | 39 | 84.5b | 1 (Ref.) | ||||
| AG | 50 (31.06) | 21 | 48.0 | 0.919 | 0.97 (0.57–1.66) | ||||
| AA | 4 (2.48) | 1 | 33.0 | 0.648 | 0.63 (0.09–4.59) | ||||
| HBV | Positive | GG | 86 (65.15) | 31 | 88.1b | 1 (Ref.) | |||
| AG | 40 (30.30) | 13 | 90.0 | 0.331 | 0.73 (0.38–1.39) | ||||
| AA | 6 (4.55) | 1 | 64.1b | 0.552 | 0.55 (0.07–4.02) | ||||
| Negative | GG | 19 (63.33) | 7 | 27.0 | 1 (Ref.) | ||||
| AG | 11 (36.67) | 4 | 25.7b | 0.803 | 1.17 (0.34–4.09) | ||||
| AA | 0 | 0 | NA | NA | NA | ||||
| H19 | rs2839698 | ||||||||
| Gender | Male | CC | 157 (56.07) | 61 | 56.0 | 1 (Ref.) | |||
| CT | 110 (39.29) | 50 | 47.0 | 0.692 | 1.08 (0.74–1.57) | ||||
| TT | 13 (4.64) | 2 | 97.5b | 0.087 | 0.29 (0.07–1.20) | ||||
| Female | CC | 25 (39.06) | 8 | 55.0 | 1 (Ref.) | ||||
| CT | 34 (53.13) | 11 | 51.0 | 0.909 | 1.05 (0.42–2.63) | ||||
| TT | 5 (7.81) | 4 | 5.0 | 0.070 | 3.14 (0.91–10.85) | ||||
| Age | ≤60 | CC | 111 (51.63) | 42 | 56.0 | 1 (Ref.) | |||
| CT | 94 (43.72) | 43 | 48.0 | 0.614 | 1.12 (0.73–1.71) | ||||
| TT | 10 (4.65) | 2 | 91.4b | 0.233 | 0.42 (0.10–1.75) | ||||
| >60 | CC | 71 (55.04) | 27 | 56.0 | 1 (Ref.) | ||||
| CT | 50 (38.76) | 18 | 79.4b | 0.838 | 0.94 (0.52–1.71) | ||||
| TT | 8 (6.20) | 4 | 27.0 | 0.681 | 1.25 (0.44–3.58) | ||||
| Smoking | Ever smoker | CC | 16 (50.00) | 2 | 127.1b | 1 (Ref.) | |||
| CT | 16 (50.00) | 9 | 45.0 | 0.035 | 5.19 (1.12–24.07) | ||||
| TT | 0 | 0 | NA | NA | NA | ||||
| Never smoked | CC | 97 (57.06) | 31 | 69.0 | 1 (Ref.) | ||||
| CT | 59 (34.71) | 23 | 47.0 | 0.624 | 1.15 (0.67–1.97) | ||||
| TT | 14 (8.23) | 5 | 75.1b | 0.792 | 0.88 (0.34–2.28) | ||||
| Alcohol drinking | Drinker | CC | 12 (63.16) | 1 | 70.2b | 1 (Ref.) | |||
| CT | 7 (36.84) | 4 | 45.0 | 0.110 | 5.99 (0.67–53.96) | ||||
| TT | 0 | 0 | NA | NA | NA | ||||
| Non-drinker | CC | 101 (55.19) | 32 | 69.0 | 1 (Ref.) | ||||
| CT | 68 (37.16) | 28 | 48.0 | 0.339 | 1.28 (0.77–2.13) | ||||
| TT | 14 (7.65) | 5 | 75.1b | 0.927 | 0.96 (0.37–2.47) | ||||
| HBV | Positive | CC | 70 (52.24) | 19 | 94.3b | 1 (Ref.) | |||
| CT | 55 (41.04) | 24 | 52.0 | 0.125 | 1.60 (0.88–2.93) | ||||
| TT | 9 (6.72) | 3 | 78.7b | 0.924 | 0.94 (0.28–3.20) | ||||
| Negative | CC | 17 (56.67) | 6 | 42.2b | 1 (Ref.) | ||||
| CT | 11 (36.67) | 3 | 58.3b | 0.882 | 0.90 (0.22–3.65) | ||||
| TT | 2 (6.66) | 2 | 2.0 | 0.229 | 2.74 (0.53–14.18) | ||||
| H19 | rs3024270 | ||||||||
| Gender | Male | GG | 114 (40.14) | 45 | 56.0 | 1 (Ref.) | |||
| CG | 131 (46.13) | 57 | 48.0 | 0.946 | 0.99 (0.67–1.46) | ||||
| CC | 39 (13.73) | 12 | 90.0 | 0.233 | 0.68 (0.36–1.28) | ||||
| Female | GG | 17 (26.15) | 4 | 55.0 | 1 (Ref.) | ||||
| CG | 28 (43.08) | 10 | 51.0 | 0.532 | 1.45 (0.45–4.65) | ||||
| CC | 20 (30.77) | 9 | 27.0 | 0.086 | 2.83 (0.87–9.28) | ||||
| Age | ≤60 | GG | 79 (36.41) | 28 | 86.7b | 1 (Ref.) | |||
| CG | 99 (45.62) | 44 | 48.0 | 0.926 | 1.02 (0.64–1.65) | ||||
| CC | 39 (17.97) | 15 | 90.0 | 0.611 | 1.18 (0.63-2.21) | ||||
| >60 | GG | 52 (39.39) | 21 | 55.0 | 1 (Ref.) | ||||
| CG | 60 (45.46) | 23 | 76.8b | 0.946 | 0.98 (0.54–1.77) | ||||
| CC | 20 (15.15 | 6 | 56.6b | 0.370 | 0.66 (0.27–1.64) | ||||
| Smoking | Ever smoker | GG | 7 (21.21) | 0 | NA | 1 (Ref.) | |||
| CG | 21 (63.64) | 10 | NA | NA | NA | ||||
| CC | 5 (15.15) | 1 | NA | NA | NA | ||||
| Never smoked | GG | 65 (37.79) | 20 | 86.3b | 1 (Ref.) | ||||
| CG | 71 (41.28) | 27 | 47.0 | 0.710 | 1.12 (0.63–1.99) | ||||
| CC | 36 (20.93) | 13 | 90.0 | 0.978 | 1.01 (0.50–2.04) | ||||
| Alcohol drinking | Drinker | GG | 7 (36.84) | 0 | NA | 1 (Ref.) | |||
| CG | 10 (52.63) | 5 | NA | 0.298 | NA | ||||
| CC | 2 (10.53) | 0 | NA | NA | NA | ||||
| Non-drinker | GG | 65 (34.95) | 20 | 91.3b | 1 (Ref.) | ||||
| CG | 82 (44.09) | 32 | 69.0 | 0.518 | 1.20 (0.69–2.11) | ||||
| CC | 39 (20.96) | 14 | 90.0 | 0.939 | 1.03 (0.52–2.04) | ||||
| HBV | Positive | GG | 45 (32.61) | 13 | 95.0b | 1 (Ref.) | |||
| CG | 63 (45.65) | 25 | 69.0 | 0.398 | 1.34 (0.68–2.62) | ||||
| CC | 30 (21.74) | 9 | 90.0 | 0.951 | 0.97 (0.42–2.28) | ||||
| Negative | GG | 12 (40.00) | 4 | 44.7b | 1 (Ref.) | ||||
| CG | 13 (43.33) | 4 | 51.5b | 0.786 | 1.22 (0.29–5.05) | ||||
| CC | 5 (16.67) | 3 | 27.0 | 0.358 | 2.03 (0.45–9.20) |
NA, not available. The bold text means the significant results.
a, MST, median survival time (months);
b, Mean survival time was provided when MST could not be calculated.